Description

What is piperonyl methyl ketone?

3,4-Methylenedioxyphenylpropan-2-one or piperonyl methyl ketone is a chemical compound consisting of a phenylacetone moiety substituted with a methylenedioxy functional group. It is also called PMK. Buy PMK online. Buy piperonyl methyl ketone online. Buy PMK online. Order PMK online.

A precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. It is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. It can be present as an impurity in preparations of methylenedioxy phenethylamines. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications. https://levelupchem.com/

Other Names of piperonyl methyl ketone: 

MDP2P
Piperonyl methyl ketone
3,4-Methylenedioxyphenylacetone
3,4-Methylenedioxyphenyl-2-propanone
PIPAC
PMK

It is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA (Item No. 13971).1 It can be present as an impurity in preparations of methylenedioxy phenethylamines.2 The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

Uses:

This chemical is used as pharmaceutical intermediate. It is also used for the synthesis of berberine, methyl dopa, antihypertensive and anti-tumor drugs. Moroever, it can react with 2-Formyl-benzoic acid to get 3-(1-Benzo[1,3]dioxol-5-yl-2-oxo-propyl)-3H-isobenzofuran-1-one. Piperonyl Methyl Ketone

Application of PMK:
Metabolite of 3,4-Methylenedioxyethylamphetamine (MDE) and 3,4-(Methylenedioxy)methamphetamine (MDMA).

Piperonyl methyl ketone is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA (Item No. 13971). It can be present as an impurity in preparations of methylenedioxy phenethylamines. https://levelupchem.com/index.php/product/amineptine-100mg/

he classic ‘ketone’ approach (certainly not the only possibility, but the best documented one) has a lot of variations, but the basic scheme is the oxidation of the plant oil safrole (1-allyl-3,4-methylenedioxybenzene) into a ketone (3,4-methylenedioxyphenyl-2-propanone), which is then condensed with methylamine and reduced to the final MDMA product. https://levelupchem.com/index.php/product/benzodiazepines/

Synonyms: 3-(1,3-benzodioxol-5-yl)-2-methyl-2-oxiranecarboxylic acid, methyl ester

Correlated keywords: Piperonyl methyl ketone glycidic methylenedioxymethylamphetamine. Piperonyl Methyl Ketone

Piperonyl methyl ketone (PMK) methyl glycidate is an analytical reference standard that is categorized as a precursor in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. This product is intended for research and forensic applications.

The classic ‘ketone’ approach has a lot of variations, but the basic scheme is the oxidation of the plant oil safrole (1-allyl-3,4-methylenedioxybenzene) into a ketone (3,4-methylenedioxyphenyl-2-propanone), which is then condensed with methylamine and reduced to the final MDMA product. Piperonyl Methyl Ketone

Step 1: Peroxyacid oxidation (requires isomerization of safrole) or Wacker oxidation (an elegant catalytic oxidation) produces the ketone “PMK” (piperonyl methyl ketone, also known as 3,4-MDP2P, or 3,4-methylenedioxyphenyl-2-propanone.)

There are a lot of oxidization reactions available, but in this case we of course want something that will produce the Markovnikov product, with addition occurring at the more substituted end of the alkene. An initial oxidation to an alcohol followed by a second oxidation step to a ketone is also a possibility.

Since safrole and PMK are carefully watched and regulated precursors, the current favorite precursor (typically bought from Chinese chemical manufacturers) is PMK glycidate. PMK glycidate can reportededly be easily broken down into PMK simply by refluxing it with hydrochloric acid. (But read on about the chemical watch lists!) Piperonyl Methyl Ketone

Step 2: Reversible imine formation (occurs spontaneously when the ketone is placed in solution with methylamine freebase (not the hydrochloride salt.)

Step 3: Reduction (via hydrides, aluminum-mercury amalgams, or electrical cells) or catalytic hydrogenation permanently converts the imine to MDMA. Since ketones and imines lack a chiral center, they (like a good Buddhist monk) do not project personal desires on the world, so the resulting product is racemic, containing a 50-50 mix of both the stronger S(+) isomer (which releases plenty of serotonin, dopamine and norepinephrine) and the weaker R(-) isomer (which is effectively just a serotonin releaser.) Piperonyl Methyl Ketone

All MDMA sold on the streets appears to be racemic. A product containing only one isomer would not subjectively feel the way racemic MDMA does, being either more amphetamine-like or more sedating and mellow (like MDEA, which seems to be primarily a serotonin releaser.)

Safrole is found in various “essential oils”, the most famous of which is sassafras oil, which can contain as much as 90% safrole. Since safrole (and isosafrole, MDP2P/PMK, and sassafrass oil) are “listed precursors” in the US they’re very hard to find. (Many remaining ‘sassafras oil’ products are now safrole-free in order to avoid regulation.) Even attempting to order one of these chemicals can bring law enforcement attention. Piperonyl Methyl Ketone

The most famous route is probably one of Shulgin’s original synths from PIHKAL (third paragraph), starting with PMK (MDP2P) made from isosafrole.

Isomerization of safrole is reportedly an easy operation, as described in the famous Strike synthesis collection. (A more compact review can be found in this old doc saved from Rhodium.)

Shulgin’s ingenious use of aluminum foil and mercury as a reducing agent opened up a lot of possibilities for hobbyist-scale clandestine labs, but it comes with one ugly downside: Highly toxic mercury compounds.

The disposal of the leftover chemical waste from clan-labs has always been an environmental and public health problem, with irresponsible chemists dumping waste in ditches or even flushing it down the drain into sewer systems. Piperonyl Methyl Ketone

Mercury-aluminum amalgam is an interesting little reagent. Aluminum has a low electronegativity, which suggests that it would react very readily with anything mildly electron-hungry (such as the carbon atom of an imine, or the hydrogen atoms of water.) And yet, aluminum is considered corrosion-resistant under most conditions, to the point that it’s even used as shipping containers for nitric acid! Piperonyl Methyl Ketone

That’s because, although aluminum does react readily, it tends to form aluminum oxide. This aluminum oxide forms a tightly interlocking crystalline layer over the remaining aluminum, sealing it off and protecting it from further reactions. Mercury is able to penetrate this protective oxide layer and prevent it from re-forming, which allows the aluminum to continue to react, contributing electrons to reduce whatever suitable chemical (oxygen, water, imines, etc.) happens to be handy.

This ability is the reason that you aren’t allowed to take or ship mercury on jets, which are usually made from aluminum. A spill of mercury could create a chemical ‘rot’ in the structure of the plane as the now unprotected aluminum continues to react with moisture and oxygen in the air. Piperonyl Methyl Ketone