What is Phenylacetone?
Phenylacetone is an organic compound with the chemical formula C₆H₅CH₂COCH₃. It is a colorless oil that is soluble in organic solvents. This substance is used in the manufacture of methamphetamine and amphetamine, where it is commonly known as P2P. Benzyl methyl ketone commonly called BMK or Benzyl methyl ketone. Buy Phenylacetone online. Buy BMK online. Buy Benzyl methyl ketone online. https://en.wikipedia.org/wiki/Amphetamine
Due to the illicit uses in clandestine chemistry, it was declared a schedule II controlled substance in the United States in 1980. In humans, Benzyl methyl ketone occurs as a metabolite of amphetamine and methamphetamine via FMO3-mediated oxidative deamination. Buy Benzyl methyl ketone online https://levelupchem.com/index.php/product/amphetamine/
Benzyl methyl ketone is the immediate precursor for clandestine production of amphetamine and methamphetamine. BMK on anaerobic incubations with rat liver mitochondria gets reduced to phenylisopropanol. Buy Phenylacetone online. https://levelupchem.com/
Other names: 2-Propanone, 1-phenyl-; Methyl benzyl ketone; Phenyl-2-propanone; Phenylacetone; 1-Phenyl-2-propanone; 3-Phenyl-2-propanone; α-Phenylacetone; Phenylmethyl methyl ketone; P2P; NSC 9827; 1-Phenylpropan-2-one; Fenproporex-M (desamino-oxo-); benzylmethylketon. Buy Phenylacetone online
CAS Registry Number: 103-79-7
Boiling point: 216 °C
Molar mass: 134.18 g/mol
Melting point: -15 °C
Density: 1.01 g/cm³
Classification: Organic compound
In the “otherwise” category, the most common use is likely as a precursor to Methamphetamine (meth) and amphetamine in clandestine production. Buy Phenylacetone online https://levelupchem.com/index.php/product/2-chlorophenyl-cyclopentyl-ketone/
It presents a density similar to that of water as well as a pleasant scent. Even if there are few legitimate uses of BMK such as in the production of the pharmaceutical drug propyl-hexedrine, most frequently BMK is used as an illicit compound for the illegal manufacture of amphetamine. Buy BMK online https://levelupchem.com/index.php/product/piperonyl-methyl-ketone/
BMK is an organic compound with the chemical formula C₆H₅CH₂COCH₃. It is also called BMK. This substance is used or precursor in the manufacture of methamphetamine and amphetamine, where it is commonly known as P2P. Buy Phenylacetone online. https://levelupchem.com/index.php/product/fenyloaceton/
What is the p2p method?
P2P method. Phenyl-2-Propanone, more commonly known as p2p is the method that Walt and Jesse use in the later parts of the show, when they move onto making meth in large quantities. The process of turning this into methamphetamine in the P2P method is called reductive amination. Buy Phenylacetone online https://levelupchem.com/index.php/product/benzyl-methyl-ketone-bmk/
Phenylacetone is the immediate precursor for clandestine production of amphetamine and methamphetamine. Phenylacetone on anaerobic incubations with rat liver mitochondria gets reduced to phenylisopropanol.
Determination of benzyl methyl ketone – A commonly used precursor in amphetamine manufacture.
Phenylacetone is the deamination product of amphetamine metabolism and has been used as a precursor in the illicit synthesis of methamphetamine and amphetamine. Phenylacetone is a product intended for forensic and research applications.
It has a density similar to that of water as well as a pleasant scent. BMK is most frequently used as a precursor for the manufacture of amphetamine. The legitimate use of BMK in the chemical and pharmaceutical industries is limited to the manufacture of amphetamine and methamphetamine and their derivatives.
Phenylacetone is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble in organic solvents. This substance is used in the manufacture of methamphetamine and amphetamine, where it is commonly known as P2P. In humans, phenylacetone occurs as a metabolite of amphetamine and methamphetamine via FMO3-mediated oxidative deamination.
Phenylacetone monooxygenase (PAMO) is an exceptionally robust Baeyer-Villiger monooxygenase, which makes it ideal for potential industrial applications.
However, its substrate scope is limited, unreactive cyclohexanone being a prominent example. Such a limitation is unfortunate, because this particular transformation in an ecologically viable manner would be highly desirable, the lactone and the respective lactam being of considerable interest as monomers in polymer science.
We have applied directed evolution in search of an active mutant for this valuable C-C activating reaction. Using iterative saturation mutagenesis (ISM), several active mutants were evolved, with only a minimal trade-off in terms of stability.
The best mutants allow for quantitative conversion of 2 mM cyclohexanone within 1 h reaction time. In order to circumvent the NADP(+) regeneration problem, whole E. coli resting cells were successfully applied. Molecular dynamics simulations and induced fit docking throw light on the origin of enhanced PAMO activity.
The PAMO mutants constitute ideal starting points for future directed evolution optimization necessary for an industrial process.
Phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols, plus small amounts of 1,2-glycols and ketols (2-one-1-ols).
Phenylacetone incubations produced small amounts of benzoic acid, which was confirmed as a true metabolite by incubation of 2H5 (phenyl-labeled) phenylacetone and corresponding recovery of phenyl-labeled benzoic acid. No benzoic acid was detectable from incubations of phenyl-2-butanone and 3-methyl-1-phenyl-2-butanone. 3-Methyl-1-phenyl-2-butanone yielded eight metabolites in addition to the corresponding alcohol, and structures are proposed for some of these metabolic products.
1-Phenyl-2-propanone (P-2-P), also known as benzyl methyl ketone (BMK), is the main precursor used in amphetamine synthesis. In recent years, the number of seizures of P-2-P from both licit and illicit drug manufacture has increased.
The present article comprises a discussion of some of the largest seizures of P-2-P diverted from regular production to the illicit market. It also presents the methods used in clandestine laboratories to synthesize P-2-P and a forensic approach to identify and differentiate between these methods.
To that end, and to facilitate the monitoring of the P-2-P market, a method of P-2-P impurity profiling was designed for comparative purposes and for the identification of the synthesis route. P-2-P samples were analysed by means of gas chromatography/mass spectrometry (GC/MS). Out of 36 identified impurities, 14 were selected as markers for sample comparison.
On the basis of the GC peak areas of those 14 markers, a cluster analysis was carried out, resulting in three clusters, each corresponding to a given P-2-P synthesis route. The results of P-2-P impurity profiling are stored in both a forensic database and a police database.
The forensic database comprises chemical data, such as those on P-2-P purity, additives and specific impurities, as well as information on seized P-2-P samples having a similar impurity profile.
Data stored in the police database, which is linked with the forensic database by case identification number, cover the circumstances of seizures and personal details of offenders. The databases enable the full use of forensic data in intelligence work and police investigative activities.
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