What is MDPV?
MDPV (Methylenedioxypyrovalerone) is a psychoactive stimulant narcotic that acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It is the active ingredient in “bath salts,” a designer drug that is knowingly labeled as ‘not for human consumption’ so that the drug is legally available on the market. Buy MDPV. https://en.wikipedia.org/wiki/Methylenedioxypyrovalerone
How Does MDPV Work?
MDPV pills as a white or light brown powder, which may be slightly clumpy and have a specific odor. https://levelupchem.com/index.php/product/testosterone-cypionate/
It binds to dopamine, serotonin, and norepinephrine transporters in the brain, preventing these neurotransmitters from being absorbed quickly. Neurotransmitters that stay available to the brain longer change mood and behaviors. In the case of stimulants like MDMA, and even meth and cocaine, the person experiences elevated physical energy, increased talkativeness and lowered inhibitions, and excitement and happiness. These positive feelings are then followed by anxiety, paranoia, and possible violence. https://levelupchem.com/
Increased heart rate – Higher doses of it can create a significant and often dangerous increase in heart rate and blood pressure.
Diarrhea – Some users have reported experiencing diarrhea while under the influence of it, although this seems to be a relatively uncommon effect.
Nausea – Some users have reported experiencing nausea while under the influence of MDPV, although this seems to be a relatively uncommon effect.
Restless leg syndrome
What does MDPV do?
An oral dose of MDPV is estimated to be around 5-20 milligrams (compared to 100-150 milligrams for MDMA). The main psychoactive effects last two to three hours, and side-effects persist for several additional hours. https://levelupchem.com/index.php/product/cocaine/
Users report it produces euphoria, feelings of empathy (although less so than MDMA), increased sociability, mental and physical stimulation, and sexual arousal. https://levelupchem.com/index.php/product/mdai/
Side-effects, particularly at high doses, can include anxiety and paranoia, delusions, muscle spasms, and an elevated heart rate. In extreme cases, It has been linked to rhabdomyolysis (rapid muscle breakdown), brain injury, and death. https://levelupchem.com/index.php/product/amphetamine/
It has been involved in dozens of deaths in Europe, detailed in a report by the European Monitoring Centre for Drugs and Drug Addiction, as well as in the United States, Australia, and elsewhere. Buy MDPV online. https://levelupchem.com/index.php/product/heroin/
3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. https://levelupchem.com/index.php/product/amineptine-100mg/
A rise in a dangerous new party drug known as “monkey dust”. This is a slang name for the drug (3,4-methylenedioxypyrovalerone), as well as other members of the chemical class known as “synthetic cathinones”, or “bath salts”.
The effects of monkey dust are similar to other stimulants such as ecstasy (MDMA) and cocaine. Revellers may be using the drug on purpose as a substitute for these, or may mistakenly think it’s MDMA. However, the potency and effects are different, and can lead to trouble. https://levelupchem.com/index.php/product/piperonyl-methyl-ketone/
Methylenedioxypyrovalerone (MDPV) is the active ingredient of a new group of synthetic psychoactive drugs, “bath salts,” that block the reuptake of dopamine and norepinephrine.
MDPV, but not mephedrone, produced stereotypic behavior in rats, and MDPV produced stereotypy in mice. Mephedrone was self-administered and increased core body temperature (rats). MDPV had only a negligible effect on body temperature.
In mice, hyperthermia following it administration was observed only at warm ambient temperatures.
It was also self-administered by rats and was more potent and efficacious than S(+)METH. MCAT, methylone, mephedrone, and MDPV facilitated intracranial self-stimulation (ICSS) in rats; MCAT displayed the highest efficacy and mephedrone the lowest.
3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive component of so-called bath salts products that has caused serious medical consequences in humans.
The neuropharmacology of MDPV and related analogs, and supplement the discussion with new results from our preclinical experiments.
It acts as a potent uptake inhibitor at plasma membrane transporters for dopamine (DAT) and norepinephrine (NET) in nervous tissue.
The MDPV formulation in bath salts is a racemic mixture, and the S isomer is much more potent than the R isomer at blocking DAT and producing abuse-related effects.
Synthetic cathinones are synthetic derivatives of a stimulant found in the khat plant, a flowering plant native to the Horn of Africa and the Arabian Peninsula. More than 140 individual synthetic cathinones have been identified as illicit drugs, so users can never be certain about a substance from its street name alone.
This class also includes drugs you may have heard of before including ephylone, methylone, and mephedrone.
Elevations in brain extracellular dopamine produced by MDPV are likely to underlie its locomotor stimulant and addictive properties.
MDPV displays rapid pharmacokinetics when injected into rats (0.5–2.0 mg/kg), with peak plasma concentrations achieved by 10-20 min and declining quickly thereafter.
MDPV is metabolized to 3,4-dihydroxypyrovalerone (3,4-catechol-PV) and 4-hydroxy-3-methoxypyrovalerone (4-OH-3-MeO-PV) in vivo, but motor activation produced by the drug is positively correlated with plasma concentrations of parent drug and not its metabolites. 3,4-Catechol-PV is a potent uptake blocker at DAT in vitro but has little activity after administration in vivo. 4-OH-3-MeO-PV is the main MDPV metabolite but is weak at DAT and NET.
MDPV analogs, such as α-pyrrolidinovalerophenone (α-PVP), display similar ability to inhibit DAT and increase extracellular dopamine concentrations.
Taken together, these findings demonstrate that MDPV and its analogs represent a unique class of transporter inhibitors with a high propensity for abuse and addiction.
Some common keywords: Addiction, Dopamine, Pyrrolidinophenones, Synthetic cathinones, Transporter, Uptake, α-PVP
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