What is 2-Chlorophenyl cyclopentyl ketone?
2–Chlorophenyl cyclopentyl ketone is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. It acts as a pharmaceutical intermediate and also as an intermediate of ketamine. Buy 2-Chlorophenyl cyclopentyl ketone online.
Synonyms: (2-Chlorobenzoyl)cyclopentane; Cyclopentyl 2-Chlorophenyl Ketone; Cyclopentyl o-Chlorophenyl Ketone; (2-Chlorophenyl)cyclopentylmethanone;
CAS Number: 6740-85-8
Molecular Formula: C₁₂H₁₃ClO
Appearance: Clear Pale Yellow Oil
Melting Point: N/A
Molecular Weight: 208.68
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Boiling Point 96°C
Physical Form: Clear Liquid at 20°C
Percent Purity: ≥98.0% (GC)
Chemical Name or Material: 2-Chlorophenyl Cyclopentyl Ketone
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals,
Applications: It is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. Buy 2-Chlorophenyl cyclopentyl ketone online
Step 1: Peroxyacid oxidation (requires isomerization of safrole) or Wacker oxidation (an elegant catalytic oxidation) produces the ketone “PMK” (piperonyl methyl ketone, also known as 3,4-MDP2P, or 3,4-methylenedioxyphenyl-2-propanone.) There are a lot of oxidization reactions available, but in this case we of course want something that will produce the Markovnikov product, with addition occurring at the more substituted end of the alkene. Buy 2-Chlorophenyl cyclopentyl ketone online
An initial oxidation to an alcohol followed by a second oxidation step to a ketone is also a possibility. Since safrole and PMK are carefully watched and regulated precursors, the current favorite precursor (typically bought from Chinese chemical manufacturers) is PMK glycidate. https://levelupchem.com/index.php/product/benzodiazepines/
PMK glycidate can reportededly be easily broken down into PMK simply by refluxing it with hydrochloric acid. (But read on about the chemical watch lists!)
Step 2: Reversible imine formation (occurs spontaneously when the ketone is placed in solution with methylamine freebase (not the hydrochloride salt.).
Step 3: Reduction (via hydrides, aluminum-mercury amalgams, or electrical cells) or catalytic hydrogenation permanently converts the imine to MDMA.
Since ketones and imines lack a chiral center, they (like a good Buddhist monk) do not project personal desires on the world, so the resulting product is racemic, containing a 50-50 mix of both the stronger S(+) isomer (which releases plenty of serotonin, dopamine and norepinephrine) and the weaker R(-) isomer (which is effectively just a serotonin releaser.) All MDMA sold on the streets appears to be racemic. Buy 2-Chlorophenyl cyclopentyl ketone online https://levelupchem.com/index.php/product/amineptine-100mg/
A product containing only one isomer would not subjectively feel the way racemic MDMA does, being either more amphetamine-like or more sedating and mellow (like MDEA, which seems to be primarily a serotonin releaser.) Safrole is found in various “essential oils”, the most famous of which is sassafras oil, which can contain as much as 90% safrole. https://levelupchem.com/
Since safrole (and isosafrole, MDP2P/PMK, and sassafrass oil) are “listed precursors” in the US they’re very hard to find. (Many remaining ‘sassafras oil’ products are now safrole-free in order to avoid regulation.) Even attempting to order one of these chemicals can bring law enforcement attention. Buy 2-Chlorophenyl cyclopentyl ketone order https://levelupchem.com/index.php/product/methaqualone-300-mg-quaaludes/
The most famous route is probably one of Shulgin’s original synths from PIHKAL (third paragraph), starting with PMK (MDP2P) made from isosafrole. Isomerization of safrole is reportedly an easy operation, as described in the famous Strike synthesis collection. (A more compact review can be found in this old doc saved from Rhodium.), Order 2-Chlorophenyl cyclopentyl ketone online
Shulgin’s ingenious use of aluminum foil and mercury as a reducing agent opened up a lot of possibilities for hobbyist-scale clandestine labs, but it comes with one ugly downside: Highly toxic mercury compounds. Buy 2-Chlorophenyl cyclopentyl ketone online https://levelupchem.com/index.php/product/piperonyl-methyl-ketone/
2-Chlorophenyl Cyclopentyl Ketone is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons.
2-Chlorophenyl cyclopentyl ketone Preparation Products And Raw materials
2-Chlorobenzoic acid Cyclopentene Thionyl chloride 2-Chlorobenzoyl chloride
KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL (METHYLIMINO)METHYL]CYLCOPENTA-NOL)
2-Chlorophenyl cyclopentyl ketone is used as a reagent in the preparation of bicyclic and polycyclic aromatic hydrocarbons. It acts as a pharmaceutical intermediate and also as an intermediate of ketamine. 2-Chlorophenyl Cyclopentyl Ketone
Notes to take: Incompatible with oxidizing agents.
synthesis of O-Chlorophenyl cyclopentyl Ketone:
I was searching for a synthesis of O-Chlorophenyl cyclopentyl Ketone (besides the classical synthesis with cyclopentyl magnesium bromide and o-chlorobenzonitrile) and found two interesting synthesis in the same publication. Chlorophenyl Cyclopentyl Ketone
Synthesis of α,β-Unsaturated Ketones via Enamines’, Synthetic
Communications, 16: 8, 957 — 965
To 1-morpholinocyclopentene (46 g, 0.30 mol) in chloroform (450 ml) was added triethylamine (31.3 g, 0.31 mol) first and then a solution of o-chlorobenzoyl chloride (54.3 g, 0.31 rnol) in chloroform (150 ml) with stirring at 38-42 degrees in about 1 hour. Stirring was continued for another hour and the reaction mixture was stood overnight.
It was washed twice with sodium carbonate solution and twice with water and after dried (MgSO4 ), chloroform was removed successively by evaporation and then thrice with anhydrous methanol to give 1C as a dark red, viscous oil. 2-Chlorophenyl Cyclopentyl Ketone
The crude (1C) was dissolved in anhydrous ethanol (150 ml) and decolorized by boiling with active charcoal (10 g) and filtered. The filtrate was hydrogenated with Adams’ Pt02 (1.0 g) at ambient pressure and temperature; hydrogen (0.3 mol) was absorbed in about 2 hour.
The resulting oil obtained after removal of catalysis and evaporation was dissolved in cold 6N HCl acid (50 ml) and extracted twice with toluene.
The combined toluene extract was washed twice with a small amount of 6N HCl acid, twice with water and dried (MgSO4) . The toluene extract was fractionated to give a mixture of (3C) and (4C), b.p. 114-132/3 mm, 17.8 g.
Some toluene (50 ml was mixed with the combined HCl acid extract and the mixture was refluxed for 2 hours. The toluene layer was separated and the acid layer was extracted once with toluene. 2-Chlorophenyl Cyclopentyl Ketone
The combined toluene layer and extract was washed twice with water and dried (MgSO4 ). Removal of toluene and distillation gave 3C b.p. 112-116°/0.l mm, 28.9 g, 46.7% yield.
O-Chlorophenyl cyclopentyl Ketone (4C).
Pure and impure 3C were combined and hydrogenated to give (4C), b.p. 94-96O/0.05 mm , 37.5 g, 60% yield.
And in the same publication comes a reference to another synthesis of the same Ketone of interest.
4C had been synthesized previously by addition of cyclopentyl magnesium bromide to o-chlorobenzonitrile and by Nenitzescu reaction of o-chlorobenzoyl chloride and cyclopentene with aluminium chloride as catalyst in cyclohexane( reference 1).. The yields obtained in both cases were less than 30%. 2-Chlorophenyl Cyclopentyl Ketone
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